If Channel Inhibition With Ivabradine Does Not Improve Cardiac and Vascular Function in Experimental Septic Shock.
Fiche publication
Date publication
septembre 2016
Journal
Shock (Augusta, Ga.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ALBUISSON Eliane
Tous les auteurs :
Wei C, Al Kattani N, Louis H, Albuisson E, Levy B, Kimmoun A
Lien Pubmed
Résumé
Previous studies have suggested that lowering heart rate (HR) by selective β1-blockers improves sepsis-induced cardiac and vascular dysfunction primarily by decreasing proinflammatory pathways. However, the impact of isolated heart rate reduction (HRR) on hemodynamics and inflammatory pathways remains unknown. The present study was designed to assess the effects of HRR by ivabradine, an If channel inhibitor, on cardiovascular function and inflammatory pathways in peritonitis-induced septic shock in rats.
Référence
Shock. 2016 Sep;46(3):297-303