Adrenal Metastasis of a Poorly Differentiated Adenocarcinoma Mimicking a Pheochromocytoma on 18F-FDOPA PET/CT.
Fiche publication
Date publication
septembre 2016
Journal
Clinical nuclear medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr AVEROUS Gerlinde, Pr KURTZ Jean-Emmanuel, Pr LANG Hervé, Pr IMPERIALE Alessio
Tous les auteurs :
Heimburger C, Averous G, Charlin E, Lang H, Kurtz JE, Imperiale A
Lien Pubmed
Résumé
We report the surprising intense uptake of F-FDOPA in a right adrenal metastasis of a poorly differentiated metastatic adenocarcinoma of unknown primary mimicking a pheochromocytoma in a hemodialyzed patient with the typical Menard's triad and increased serum catecholamines. Our observation emphasizes that F-FDOPA is not a specific radiotracer for pheochromocytoma and paraganglioma investigation, although it is currently and successfully used in this clinical setting. Moreover, we underline that kidney failure may be responsible for abnormally high serum catecholamines values even in subjects without pheochromocytoma, leading to erroneous diagnostic conclusions particularly in patients with adrenal masses.
Mots clés
Adenocarcinoma, diagnostic imaging, Adrenal Gland Neoplasms, diagnostic imaging, Adult, Diagnosis, Differential, Dihydroxyphenylalanine, analogs & derivatives, Fatal Outcome, Fluorine Radioisotopes, Humans, Male, Pheochromocytoma, diagnostic imaging, Positron Emission Tomography Computed Tomography
Référence
Clin Nucl Med. 2016 Sep;41(9):691-2