Preparation of core/shell NaYF:Yb,Tm@dendrons nanoparticles with enhanced upconversion luminescence for in vivo imaging.
Fiche publication
Date publication
octobre 2016
Journal
Nanomedicine : nanotechnology, biology, and medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BEGIN-COLIN Sylvie, Dr FELDER-FLESCH Delphine
Tous les auteurs :
Francolon N, Boyer D, Leccia F, Jouberton E, Walter A, Bordeianu C, Parat A, Felder-Flesch D, Begin-Colin S, Miot-Noirault E, Chezal JM, Mahiou R
Lien Pubmed
Résumé
Upconverting nanoparticles (UCNPs) were successfully dendronized for fluorescence medical imaging applications. The structural and morphological characterizations of resulting core/shell NaYF:Yb,Tm@dendrons nanoparticles were performed by means of X-ray diffraction, infrared spectroscopy and transmission electron microscopy. In vitro cytotoxicity assays have evidenced their low toxicity. In vivo fluorescence imaging study was performed in mice upon IR excitation, showing promising imaging capacities at low concentrations (0.5mg/mL) and low power (50mW/cm).
Mots clés
Animals, Dendrimers, Luminescence, Mice, Microscopy, Electron, Transmission, Nanoparticles, X-Ray Diffraction
Référence
Nanomedicine. 2016 10;12(7):2107-2113