Chronic hepatitis C virus infection and pathogenesis of hepatocellular carcinoma.
Fiche publication
Date publication
octobre 2016
Journal
Current opinion in virology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas
Tous les auteurs :
Bandiera S, Billie Bian C, Hoshida Y, Baumert TF, Zeisel MB
Lien Pubmed
Résumé
Hepatitis C virus (HCV) infection is one of the major causes of advanced liver disease and hepatocellular carcinoma (HCC) worldwide. While the knowledge about the molecular virology of HCV infection has markedly advanced, the molecular mechanisms of disease progression leading to fibrosis, cirrhosis and HCC are still unclear. Accumulating experimental and clinical studies indicate that HCV may drive hepatocarcinogenesis directly via its proteins or transcripts, and/or indirectly through induction of chronic liver inflammation. Despite the possibility to eradicate HCV infection through direct-acting antiviral treatment, the risk of HCC persists although specific biomarkers to estimate this risk are still missing. Thus, a better understanding of HCV-induced HCC and more physiological liver disease models are required to prevent cancer development.
Mots clés
Carcinoma, Hepatocellular, pathology, Hepatitis C, Chronic, complications, Humans, Liver Cirrhosis, complications, Models, Biological
Référence
Curr Opin Virol. 2016 10;20:99-105