"Pro-youthful" factors in the "labyrinth" of cardiac rejuvenation.
Fiche publication
Date publication
octobre 2016
Journal
Experimental gerontology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VERGELY Catherine
Tous les auteurs :
Rochette L, Vergely C
Lien Pubmed
Résumé
The mechanisms of aging and senescence include various endogenous and exogenous factors. Among cardiovascular diseases, heart failure is a typical age-related disease. New strategies to restore cardiomyocyte cells have been reported: endogenous substances that can regenerate the heart's cardiomyocytes have been described: follistatin like 1 (FSTL1), growth-differentiation factor 11 (GDF11) and insulin-like growth factor 1 (IGF-I). Manipulation of the different anti and pro- pathways is essential to discover new approaches to regenerative therapies.
Référence
Exp. Gerontol.. 2016 Oct;83:1-5