The effects of alpha-cypermethrin exposure on biochemical and redox parameters in pregnant rats and their newborns.
Fiche publication
Date publication
novembre 2016
Journal
Pesticide biochemistry and physiology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NARCE Michel
Tous les auteurs :
Hocine L, Merzouk H, Merzouk SA, Ghorzi H, Youbi M, Narce M
Lien Pubmed
Résumé
Pyrethroid insecticides are extensively used in agriculture and in household activities. During pregnancy, they might affect maternal metabolic status and there after fetal development. In this work, we studied metabolic and redox effects of low dose alpha-cypermethrin exposure in pregnant rats and their offspring. The diet containing alpha cypermethrin at 0.02mg/kg/day was consumed during the entire gestation. Plasma biochemical parameters as well as liver lipid and oxidative stress markers were determined. Our results showed that alpha-cypermethrin induced an increase in body weight and in plasma glucose and lipid levels, as well as in plasma aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase activities in pregnant rats and their newborns. Pregnant rats showed cellular oxidative stress and altered oxidant-antioxidant status when treated by the insecticide and these disturbances were also seen in their newborns. In conclusion, low dose alpha-cypermethrin exposure induced several metabolic and redox alterations leading to maternal physiological impairments and to fetal metabolic changes. Alpha-cypermethrin should be used with caution especially during pregnancy.
Mots clés
Alanine Transaminase, blood, Animals, Animals, Newborn, Aspartate Aminotransferases, blood, Blood Glucose, analysis, Body Weight, drug effects, Female, Glutathione, metabolism, Insecticides, toxicity, Lipids, blood, Liver, drug effects, Malondialdehyde, metabolism, Maternal-Fetal Exchange, Metabolic Diseases, blood, Oxidation-Reduction, Oxidative Stress, drug effects, Pregnancy, Prenatal Exposure Delayed Effects, Pyrethrins, toxicity, Rats, Rats, Wistar
Référence
Pestic Biochem Physiol. 2016 Nov;134:49-54