Histopathological study of six types of adverse cutaneous drug reactions using granulysin expression.
Fiche publication
Date publication
novembre 2016
Journal
International journal of dermatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CRIBIER Bernard
Tous les auteurs :
Weinborn M, Barbaud A, Truchetet F, Beurey P, Germain L, Cribier B
Lien Pubmed
Résumé
Few studies have been published on the histopathology of cutaneous adverse drug reactions (CADR), and most of these lack information on skin allergological tests. The histopathology of drug reaction with eosinophilia and systemic symptoms (DRESS) is also seldom described. The purpose of our study was to examine six types of well-documented CADR (maculopapular exanthema, DRESS, fixed drug eruption, Stevens-Johnson syndrome, toxic epidermal necrolysis [TEN], and acute generalized exanthematous pustulosis) using histopathology and immunohistochemistry to evaluate the expression of granulysin, a key molecule in TEN.
Référence
Int. J. Dermatol.. 2016 Nov;55(11):1225-1233