Fibroblast Growth Factor 23 drives MMP13 expression in human osteoarthritic chondrocytes in a Klotho-independent manner.
Fiche publication
Date publication
novembre 2016
Journal
Osteoarthritis and cartilage
Auteurs
Membres identifiés du Cancéropôle Est :
Pr JOUZEAU Jean-Yves, Pr MAINARD Didier
Tous les auteurs :
Bianchi A, Guibert M, Cailotto F, Gasser A, Presle N, Mainard D, Netter P, Kempf H, Jouzeau JY, Reboul P
Lien Pubmed
Résumé
Fibroblast Growth Factor 23 (FGF23) may represent an attractive candidate that could participate to the osteoarthritic (OA)-induced phenotype switch of chondrocytes. To address this hypothesis, we investigated the expression of FGF23, its receptors (FGFRs) and co-receptor (Klotho) in human cartilage and studied the effects of rhFGF23 on OA chondrocytes.
Référence
Osteoarthr. Cartil.. 2016 Nov;24(11):1961-1969