Versatile Synthetic Approach for Selective Diversification of Bicyclic Aza-Diketopiperazines.
Fiche publication
Date publication
novembre 2018
Journal
ACS omega
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HIBERT Marcel, Dr BONNET Dominique
Tous les auteurs :
Péron F, Riché S, Lesur B, Hibert M, Breton P, Fourquez JM, Girard N, Bonnet D
Lien Pubmed
Résumé
Herein, we report a convenient synthesis of unprecedented aza-diketopiperazines (aza-DKPs). The strategy is based on selective diversification of bicyclic aza-DKP scaffolds by click reaction, N-acylation, and/or N-alkylation. These scaffolds containing either azido or amino groups were obtained by a key Rh(I)-catalyzed hydroformylative cyclohydrocarbonylation reaction of allyl-substituted aza-DKP. The methodology is readily amenable to the parallel synthesis of original aza-DKPs to enlarge the chemical diversity of aza-heterocycles.
Référence
ACS Omega. 2018 Nov 30;3(11):15182-15192