Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation.
Fiche publication
Date publication
août 2019
Journal
Nanoscale
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MANO João F.
Tous les auteurs :
Bjørge IM, Choi IS, Correia CR, Mano JF
Lien Pubmed
Résumé
Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.
Référence
Nanoscale. 2019 Aug 27;: