Small size apolipoprotein(a) isoforms enhance inflammatory and proteolytic potential of collagen-primed monocytes.
Fiche publication
Date publication
août 2019
Journal
Lipids in health and disease
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe
Tous les auteurs :
Sabbah N, Jaisson S, Garnotel R, Anglés-Cano E, Gillery P
Lien Pubmed
Résumé
Atherosclerosis is an inflammatory process involving activation of monocytes recruited by various chemoattractant factors, among which lipoprotein(a) and its specific apolipoprotein apo(a). Lp(a) contains a specific apolipoprotein apo(a) which size is determined by a variable number of repeats of a specific structural domain, the kringle IV type 2 (IV-2). Lp(a) plasma concentration and apo(a) size is inversely correlated, and smaller apo(a) are major risk factors for coronary heart disease.
Mots clés
Apolipoprotein(a), Atherosclerosis, Collagen, Lipoprotein(a), Monocytes
Référence
Lipids Health Dis. 2019 Aug 31;18(1):166