Concise Review: In Vitro Formation of Bone-Like Nodules Sheds Light on the Application of Stem Cells for Bone Regeneration.
Fiche publication
Date publication
novembre 2016
Journal
Stem cells translational medicine
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GANGLOFF Sophie, Dr KERDJOUDJ Halima
Tous les auteurs :
Mechiche Alami S, Gangloff SC, Laurent-Maquin D, Wang Y, Kerdjoudj H
Lien Pubmed
Résumé
: Harnessing the differentiation of stem cells into bone-forming cells represents an intriguing avenue for the creation of functional skeletal tissues. Therefore, a profound understanding of bone development and morphogenesis sheds light on the regenerative application of stem cells in orthopedics and dentistry. In this concise review, we summarize the studies deciphering the mechanisms that govern osteoblast differentiation in the context of in vitro formation of bone-like nodules, including morphologic and molecular events as well as cellular contributions to mineral nucleation, occurring during osteogenic differentiation of stem cells. This article also highlights the limitations of current translational applications of stem cells and opportunities to use the bone-like nodule model for bone regenerative therapies.
Référence
Stem Cells Transl Med. 2016 Nov;5(11):1587-1593