Eukaryotic Ribosome as a Target for Cardiovascular Disease.
Fiche publication
Date publication
novembre 2016
Journal
Cell chemical biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr YUSUPOVA Gulnara
Tous les auteurs :
Pellegrino S, Yusupova G
Lien Pubmed
Résumé
Cardiovascular diseases have been associated with genetic variants and increased plasma level of the secreted protein PCSK9. In this issue of Cell Chemical Biology, Petersen et al. (2016) describe an inhibitor of PCSK9 secretion in human cells that, surprisingly, targets the 80S ribosome.
Référence
Cell Chem Biol. 2016 Nov 17;23(11):1319-1321