Invasive Fungal Disease, Isavuconazole Treatment Failure, and Death in Acute Myeloid Leukemia Patients.
Fiche publication
Date publication
septembre 2019
Journal
Emerging infectious diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BERCEANU Ana, Dr DAGUINDAU Etienne
Tous les auteurs :
Bellanger AP, Berceanu A, Scherer E, Desbrosses Y, Daguindau E, Rocchi S, Millon L
Lien Pubmed
Résumé
We present 2 fatal cases of invasive fungal disease with isavuconazole treatment failure in immunocompromised patients: one with a TR34-L98H azole-resistant Aspergillus fumigatus isolate and the other a Rhizomucor-A. fumigatus co-infection. Such patients probably require surveillance by galactomannan antigen detection and quantitative PCRs for A. fumigatus and Mucorales fungi.
Mots clés
Aspergillus fumigatus, CT, France, Rhizomucor, acute myeloid leukemia, antimicrobial resistance, aspergillosis, computed tomography, death, fungal co-infection, fungi, galactomannan antigen, graft-versus-host disease, hematopoietic stem-cell transplantation, immunocompromised patients, invasive fungal disease, isavuconazole, mucormycosis, qPCR, quantitative PCR, treatment failure
Référence
Emerging Infect. Dis.. 2019 Sep;25(9):1778-1779