BODIPY: A Highly Versatile Platform for the Design of Bimodal Imaging Probes.
Fiche publication
Date publication
septembre 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BRUNOTTE François
Tous les auteurs :
Lhenry D, Larrouy M, Bernhard C, Goncalves V, Raguin O, Provent P, Moreau M, Collin B, Oudot A, Vrigneaud JM, Brunotte F, Goze C, Denat F
Lien Pubmed
Résumé
In molecular imaging, multimodal imaging agents can provide complementary information, for improving the accuracy of disease diagnosis or enhancing patient management. In particular, optical/nuclear imaging may find important preclinical and clinical applications. To simplify the preparation of dual-labeled imaging agents, we prepared versatile monomolecular multimodal imaging probe (MOMIP) platforms containing both a fluorescent dye (BODIPY) and a metal chelator (polyazamacrocycle). One of the MOMIP was conjugated to a cyclopeptide (i.e., octreotide) and radiolabeled with (111) In. In vitro and in vivo studies of the resulting bioconjugate were conducted, highlighting the potential of these BODIPY-based bimodal probes. This work also confirmed that the biovector and/or the bimodal probes must be chosen carefully, due to the impact of the MOMIP on the overall properties of the resulting imaging agent.
Référence
Chemistry. 2015 Sep 7;21(37):13091-9