Effects of low doses of esmolol on cardiac and vascular function in experimental septic shock.
Fiche publication
Date publication
décembre 2016
Journal
Critical care (London, England)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ALBUISSON Eliane
Tous les auteurs :
Wei C, Louis H, Schmitt M, Albuisson E, Orlowski S, Levy B, Kimmoun A
Lien Pubmed
Résumé
Administration of a selective β1-blocker, such as esmolol, in human septic shock has demonstrated cardiovascular protective effects related to heart rate reduction. Certain experimental data also indicate that esmolol exerts systemic anti-inflammatory and beneficial effects on vascular tone. Thus, the present study aimed to determine whether a non-chronotropic dose of esmolol maintains its protective cardiovascular and anti-inflammatory effects in experimental septic shock.
Référence
Crit Care. 2016 Dec;20(1):407