Chronic inflammatory demyelinating polyradiculoneuropathy: A new animal model for new therapeutic targets.
Fiche publication
Date publication
décembre 2016
Journal
Revue neurologique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DE SEZE Jérôme
Tous les auteurs :
de Sèze J, Kremer L, Alves do Rego C, Taleb O, Lam D, Beiano W, Mensah-Nyagan G, Trifilieff E, Brun S
Lien Pubmed
Résumé
Animal models are fundamental to advance knowledge of disease pathogenesis and to test/develop new therapeutic strategies. Most of the current knowledge about the pathogenic mechanisms underpinning autoimmune demyelination processes implicating autoantigens has been obtained using the Experimental Autoimmune Neuritis (EAN) animal model. The most widely used EAN model is obtained by active immunization of Lewis rats using a peptide, P0 (180-199), issuing from the major peripheral nervous system myelin protein. But this model mimics only the classical monophasic acute form of demyelinating polyradiculoneuropathy, i.e. Guillain-Barré syndrome (GBS). We developed a new model by immunizing Lewis rats using the same immunodominant neuritogenic peptide P0 (180-199) but this time with its S-palmitoyl derivative, S-palm P0 (180-199). All of the animals immunized with the S-palm P0 (180-199) peptide developed a chronic relapsing-remitting form of the disease corresponding to the electrophysiological criteria of demyelination (slow sensory nerve conduction velocity, prolonged motor nerve latency, partial motor nerve conduction blocks) with axon degeneration. These findings were confirmed by immunohistopathology study and thus, appear to mimic human chronic inflammatory demyelinating polyradiculopathy (CIDP). This new model opens up new avenues of research for testing new anti-inflammatory and neuroprotective therapeutic strategies.
Mots clés
Animals, Demyelinating Diseases, chemically induced, Disease Models, Animal, Immunohistochemistry, Motor Neurons, Neural Conduction, Neuritis, Autoimmune, Experimental, Palmitic Acid, chemistry, Polyradiculoneuropathy, Chronic Inflammatory Demyelinating, chemically induced, Rats, Rats, Inbred Lew
Référence
Rev. Neurol. (Paris). 2016 Dec;172(12):767-769