Effect of portal vein ligation on tumor growth and liver regeneration in rat cirrhotic liver lobes.
Fiche publication
Date publication
mai 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr AYAV Ahmet
Tous les auteurs :
Xu R, Yuan YF, Ayav A, Jiang CQ, Bresler L, Liu ZS, Tran N
Lien Pubmed
Résumé
The aim of the present study was to investigate the effect of portal vein ligation (PVL) on the tumor growth rate and liver regeneration in rat cirrhotic liver lobes. A total of 45 male Wistar rats were randomly divided into PVL, hepatic tumor (HT) and HT + PVL groups (n=15 per group). Liver regeneration and tumor growth in ligated and non-ligated lobes were evaluated prior to and following PVL. In addition, serum alanine transaminase, total bilirubin levels and liver tissue samples were evaluated. The results indicated that PVL induced apparent hypertrophy in normal and HT rats. However, the ratio of non-ligated lobes to total liver weight or body weight in the HT + PVL group was significantly lower when compared with the PVL group (P
Référence
Exp Ther Med. 2014 May;7(5):1089-1094