rs2476601 polymorphism in is associated with Crohn's disease but not with ulcerative colitis: a meta-analysis of 16,838 cases and 13,356 controls.
Fiche publication
Date publication
janvier 2017
Journal
Annals of gastroenterology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VUITTON Lucine
Tous les auteurs :
Hedjoudje A, Cheurfa C, Briquez C, Zhang A, Koch S, Vuitton L
Lien Pubmed
Résumé
Although the rs2476601 polymorphism of has been reported to be a susceptibility gene for Crohn's disease (CD), results from different studies vary and remain inconclusive. Also, no association has been found between rs2476601 and the risk of ulcerative colitis (UC). The aim of this meta-analysis was to investigate the association between this polymorphism (rs2476601) and the risk of inflammatory bowel disease, UC and CD.
Mots clés
Meta-analysis, PTPN22, candidate gene study, inflammatory bowel disease, polymorphism
Référence
Ann Gastroenterol. 2017 ;30(2):197-208