Roles of Retinoic Acid in Germ Cell Differentiation.
Fiche publication
Date publication
janvier 2017
Journal
Current topics in developmental biology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr TELETIN Marius, Dr MARK Manuel
Tous les auteurs :
Teletin M, Vernet N, Ghyselinck NB, Mark M
Lien Pubmed
Résumé
The modalities of gametogenesis differ markedly between sexes. Female are born with a definitive reserve of oocytes whose size is crucial to ensure fertility. Male fertility, in contrast, relies on a tightly regulated balance between germ cell self-renewal and differentiation, which operates throughout life, according to recurring spatial and temporal patterns. Genetic and pharmacological studies conducted in the mouse and discussed in this review have revealed that all-trans retinoic acid and its nuclear receptors are major players of gametogenesis and are instrumental to fertility in both sexes.
Référence
Curr. Top. Dev. Biol.. 2017 ;125:191-225