Nanoengineered implant as a new platform for regenerative nanomedicine using 3D well-organized human cell spheroids.
Fiche publication
Date publication
janvier 2017
Journal
International journal of nanomedicine
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BENKIRANE-JESSEL Nadia, Dr BRASSE David, Dr IDOUX-GILLET Ysia
Tous les auteurs :
Keller L, Idoux-Gillet Y, Wagner Q, Eap S, Brasse D, Schwinté P, Arruebo M, Benkirane-Jessel N
Lien Pubmed
Résumé
In tissue engineering, it is still rare today to see clinically transferable strategies for tissue-engineered graft production that conclusively offer better tissue regeneration than the already existing technologies, decreased recovery times, and less risk of complications. Here a novel tissue-engineering concept is presented for the production of living bone implants combining 1) a nanofibrous and microporous implant as cell colonization matrix and 2) 3D bone cell spheroids. This combination, double 3D implants, shows clinical relevant thicknesses for the treatment of an early stage of bone lesions before the need of bone substitutes. The strategy presented here shows a complete closure of a defect in nude mice calvaria after only 31 days. As a novel strategy for bone regenerative nanomedicine, it holds great promises to enhance the therapeutic efficacy of living bone implants.
Mots clés
Animals, Bone Regeneration, drug effects, Calcification, Physiologic, drug effects, Cell Culture Techniques, methods, Humans, Mice, Nude, Nanomedicine, methods, Nanoparticles, chemistry, Nanotechnology, methods, Osteoblasts, cytology, Polymers, pharmacology, Porosity, Prostheses and Implants, Regenerative Medicine, methods, Spheroids, Cellular, cytology, Tissue Engineering, Tissue Scaffolds, chemistry
Référence
Int J Nanomedicine. 2017 ;12:447-457