Desensitization of the cough reflex during limb muscle contraction in anesthetized rabbits.
Fiche publication
Date publication
février 2014
Journal
Pulmonary pharmacology & therapeutics
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHENUEL Bruno, Pr POUSSEL Mathias
Tous les auteurs :
Poussel M, Bosser G, Varechova S, Demoulin B, Chalon B, Ruckebusch O, Tiotiu A, Renaud P, Schweitzer C, Chenuel B
Lien Pubmed
Résumé
The 'cough network' exhibits plasticity at the sensor and integration levels leading to modulation of the strength or pattern of the cough reflex. Little is known about the interactions between cough and human activities, especially during exercise. The present study was designed to determine whether exercise, mimicked by electrically induced muscle contractions, can modify the incidence and/or strength of cough following mechanical stimulation of the trachea in anesthetized rabbits. Thirteen anesthetized, tracheotomized rabbits were studied by a total of 311 tracheal stimulations: 196 at rest and 115 during exercise. During muscle contractions, the incidence of the cough reflex (CR) decreased and the expiration reflex (ER) increased (p < 0.0001). The sensitivity of the CR and ER both decreased during exercise compared to the sensitivity of the CR at rest (p < 0.02), while the strength of the expulsive response remained unchanged. These results indicate that adjustments occurring during muscle contractions likely downregulate tracheal defensive reflexes in anesthetized rabbits.
Mots clés
Animals, Cough, metabolism, Exhalation, physiology, Muscle Contraction, physiology, Physical Conditioning, Animal, physiology, Physical Stimulation, Rabbits, Reflex, physiology, Trachea, physiology
Référence
Pulm Pharmacol Ther. 2014 Feb;27(1):96-101