Administration of donor apoptotic cells: an alternative cell-based therapy to induce tolerance?
Fiche publication
Date publication
mai 2003
Journal
Transplantation
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PERRUCHE Sylvain
Tous les auteurs :
Kleinclauss F, Perruche S, Cahn JY, Tiberghien P, Saas P
Lien Pubmed
Résumé
Apoptotic cells are endowed with immunomodulatory properties. The authors propose infusing apoptotic cells as a cell-based therapy product to facilitate allogeneic hematopoietic engraftment after a nonmyeloablative conditioning regimen. Such an approach may be used to obtain macrochimerism in combined hematopoietic cells and solid organ transplantation. In this article, the authors describe the mechanisms of combined hematopoietic and organ allograft transplantation and the potential difficulties. The authors discuss how intravenous apoptotic cell infusion may influence the outcome of combined transplantation. This may prove to be an interesting approach for future development in cell therapy.
Mots clés
Animals, Apoptosis, Cell Physiological Phenomena, Cell Transplantation, Humans, Tissue Donors, Transplantation Conditioning, methods, Transplantation Immunology, Transplantation Tolerance
Référence
Transplantation. 2003 May;75(9 Suppl):43S-45S