Bioinspired bone therapies using naringin: applications and advances.
Fiche publication
Date publication
juin 2018
Journal
Drug discovery today
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MANO João F.
Tous les auteurs :
Lavrador P, Gaspar VM, Mano JF
Lien Pubmed
Résumé
The use of natural compounds for treating chronic bone diseases holds remarkable potential. Among these therapeutics, naringin, a flavanone glycoside, represents one of the most promising candidates owing to its multifaceted effect on bone tissues. This review provides an up-to-date overview on naringin applications in the treatment of bone disorders, such as osteoporosis and osteoarthritis, and further highlights its potential for stem cell pro-osteogenic differentiation therapies. A critical perspective on naringin clinical translation is also provided. The topic is discussed in light of recently developed biomaterial-based approaches that potentiate its bioavailability and bioactivity. Overall, the reported pro-osteogenic, antiresorptive and antiadipogenic properties establish this flavanone as an exciting candidate for application in bone tissue engineering and regenerative medicine.
Mots clés
Animals, Biocompatible Materials, therapeutic use, Bone Diseases, drug therapy, Bone and Bones, drug effects, Flavanones, therapeutic use, Humans
Référence
Drug Discov. Today. 2018 06;23(6):1293-1304