Prophylaxis of non-communicable diseases: Why fruits and vegetables may be better chemopreventive agents than dietary supplements based on isolated phytochemicals?
Fiche publication
Date publication
juillet 2019
Journal
Current pharmaceutical design
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LIZARD Gérard
Tous les auteurs :
Koss-Mikołajczyk I, Baranowska M, Todorovic V, Albini A, Sansone C, Andreoletti P, Cherkaoui-Malki M, Lizard G, Noonan D, Sobajic S, Bartoszek A
Lien Pubmed
Résumé
World Health Organization (WHO) report from 2014 documented that non-communicable so-called civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over past 20 years has provided data suggesting that diet is an essential factor influencing risk of development of these diseases. The increasing knowledge on chemopreventive properties of certain food ingredients, in particular those of plant origin, opened the discussion on the possibility to use edible plants or their active components in the prevention of these chronic diseases. Health promoting properties of plant foods are associated with the presence of secondary metabolites that can affect many biological mechanisms of critical importance to proper functioning of the human organism. Particularly numerous are investigations indicating strong physiological effects of bioactive plant phenols belonging to the flavonoid family. These observations initiated mass production of dietary supplements containing flavonoids commercialized under the name antioxidants, even if their chemical properties did not justify such a term. However, epidemiological studies revealed that isolated bioactive phytochemicals are not as effective as fruits and vegetables containing these substances whereas they are of interest of functional food industry. In this paper, the critical assessment of reasons of this turn of events has been attempted and the concept of food synergy suggested as a future strategy of dietary chemoprevention.
Mots clés
antioxidants, bioactive phytochemicals, cancer, chemoprevention, civilization diseases, flavonoids, food synergy
Référence
Curr. Pharm. Des.. 2019 Jul 1;: