-
Fiche publication
Date publication
novembre 2016
Journal
Bulletin du cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier, Dr GODET Yann, Dr GALAINE Jeanne
Tous les auteurs :
Galaine J, Godet Y, Adotévi O
Lien Pubmed
Résumé
T cells activation is a finely regulated process to establish an effective anti-infectious or antitumor immune response while avoiding harmful autoimmune reactions. Although T cells are considered to be the main protagonists of the antitumor immune response, they act in interaction with other immune cells. The meeting of naive T cells with dendritic cells induces their differentiation into effector cells following the recognition of the peptide-MHC complex by the T cell receptor. The interaction of costimulatory molecules present on the surface of T cells with their ligand (s) expressed by mature dendritic cells contribute to the optimal T cell activation and to the formation of the immunological synapse. Conversely, engagement of inhibitory receptors expressed by T cells induces a negative feedback involved in the T cells homeostasis but also in the tumor escape from the immune system. The integration of stimulatory signals contributes to the proliferation, the survival and the differentiation of T cells whereas the inhibitory signals permit their regulation. The better understanding of T cell activation mechanisms has led to the development of therapeutic strategies aimed at stimulating the antitumor immune response or alleviating the immunosuppression.
Mots clés
Cellules dendritiques, Complexe majeur, Costimulatory molecules, Dendritic cells, Immune checkpoints, Lymphocytes T, Major histocompatibility, Molécules de, Points de contrôle, T cells, complex, costimulation, d’histocompatibilité, immunologiques
Référence
Bull Cancer. 2016 Nov;103 Suppl 1:S127-S131