Hybrid titanium/biodegradable polymer implants with an hierarchical pore structure as a means to control selective cell movement.
Fiche publication
Date publication
janvier 2011
Journal
PloS one
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LAVALLE Philippe, Pr DEBRY Christian
Tous les auteurs :
Vrana NE, Dupret A, Coraux C, Vautier D, Debry C, Lavalle P
Lien Pubmed
Résumé
In order to improve implant success rate, it is important to enhance their responsiveness to the prevailing conditions following implantation. Uncontrolled movement of inflammatory cells and fibroblasts is one of these in vivo problems and the porosity properties of the implant have a strong effect on these. Here, we describe a hybrid system composed of a macroporous titanium structure filled with a microporous biodegradable polymer. This polymer matrix has a distinct porosity gradient to accommodate different cell types (fibroblasts and epithelial cells). The main clinical application of this system will be the prevention of restenosis due to excessive fibroblast migration and proliferation in the case of tracheal implants.
Mots clés
3T3 Cells, Animals, Biocompatible Materials, pharmacology, Biodegradation, Environmental, drug effects, Cell Movement, drug effects, Cell Proliferation, drug effects, Coronary Restenosis, therapy, Epithelial Cells, cytology, Humans, Materials Testing, Mice, Nanostructures, chemistry, Polymers, pharmacology, Porosity, drug effects, Prostheses and Implants, Surface Properties, Titanium, pharmacology
Référence
PLoS ONE. 2011 ;6(5):e20480