IBD immunopathogenesis: A comprehensive review of inflammatory molecules.
Fiche publication
Date publication
avril 2017
Journal
Autoimmunity reviews
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PEYRIN-BIROULET Laurent
Tous les auteurs :
Park JH, Peyrin-Biroulet L, Eisenhut M, Shin JI
Lien Pubmed
Résumé
Inflammatory molecules play a crucial role in the pathogenesis of inflammatory bowel disease (IBD) such as ulcerative colitis and Crohn's disease, both of which are chronic inflammatory conditions of the gastrointestinal tract. Abnormal expressions of pro- and anti-inflammatory molecules have been described to cause an imbalance to the gut innate and adaptive immunity, and recently a large portion of research in IBD has been geared towards identifying novel molecules that may be used as potential therapeutic targets. Understanding of these inflammatory molecules has suggested that although ulcerative colitis and Crohn's disease share many common clinical symptoms and signs, they are in fact two separate clinical entities characterized by different immunopathogenesis. In this review, we comprehensively discuss the roles of numerous inflammatory molecules including but not limited to cytokines, chemokines, inflammasomes, microRNAs and neuropeptides and their expression status in ulcerative colitis and Crohn's disease in relation to their effects on the overall intestinal inflammatory process.
Mots clés
Anti-Inflammatory Agents, therapeutic use, Colitis, Ulcerative, diagnosis, Crohn Disease, diagnosis, Humans, Inflammasomes, metabolism, Inflammatory Bowel Diseases, immunology
Référence
Autoimmun Rev. 2017 Apr;16(4):416-426