A Treat-to-Target Update in Ulcerative Colitis: A Systematic Review.
Fiche publication
Date publication
juin 2019
Journal
The American journal of gastroenterology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PEYRIN-BIROULET Laurent
Tous les auteurs :
Ungaro R, Colombel JF, Lissoos T, Peyrin-Biroulet L
Lien Pubmed
Résumé
In 2015, the Selecting Therapeutic Targets in Inflammatory Bowel Disease (STRIDE) program proposed shifting the therapeutic focus on ulcerative colitis (UC) toward altering the natural history of the disease course by regularly monitoring objective measurements of disease activity and tailoring treatment accordingly. The therapeutic paradigm shift was well received in the research community and is often cited. However, new evidence on optimal UC treatment targets continues to accumulate since the time of the STRIDE guidelines. This systematic review summarizes the evidence accrued since the STRIDE UC recommendations, discusses the barriers for adoption of treat-to-target approaches in clinical practice in UC, and suggests directions for future research.
Référence
Am. J. Gastroenterol.. 2019 Jun;114(6):874-883