Cytomegalovirus load in inflamed intestinal tissue is predictive of resistance to immunosuppressive therapy in ulcerative colitis.
Fiche publication
Date publication
novembre 2011
Journal
The American journal of gastroenterology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr OUSSALAH Abderrahim, Pr PEYRIN-BIROULET Laurent
Tous les auteurs :
Roblin X, Pillet S, Oussalah A, Berthelot P, Del Tedesco E, Phelip JM, Chambonnière ML, Garraud O, Peyrin-Biroulet L, Pozzetto B
Lien Pubmed
Résumé
Previous studies have suggested an association between cytomegalovirus (CMV) infection and steroid-refractory inflammatory bowel disease. In this study, the use of CMV DNA load during acute flare-ups of ulcerative colitis (UC) to predict resistance to immunosuppressive therapy was evaluated in intestinal tissue.
Mots clés
Adrenal Cortex Hormones, therapeutic use, Adult, Antibodies, Viral, blood, Antiviral Agents, therapeutic use, Colitis, Ulcerative, drug therapy, Cytomegalovirus, immunology, Cytomegalovirus Infections, complications, DNA, Viral, analysis, Drug Resistance, Female, Ganciclovir, therapeutic use, Humans, Immunosuppressive Agents, therapeutic use, Intestinal Mucosa, virology, Male, Middle Aged, Prospective Studies, ROC Curve, Real-Time Polymerase Chain Reaction, Viral Load
Référence
Am. J. Gastroenterol.. 2011 Nov;106(11):2001-8