Diagnostic and Prognostic Value of Circulating Tumor Cells in Head and Neck Squamous Cell Carcinoma: a systematic review and meta-analysis.
Fiche publication
Date publication
février 2016
Journal
Scientific reports
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DE CARVALHO BITTENCOURT Marcelo, Pr FAURE Gilbert, Pr GALLET Patrice
Tous les auteurs :
Wu XL, Tu Q, Faure G, Gallet P, Kohler C, Bittencourt Mde C
Lien Pubmed
Résumé
Several techniques have been developed to detect circulating tumor cells (CTC) in patients with head and neck squamous cell carcinoma (HNSCC), but their diagnostic and prognostic value are not yet fully established. A computerized retrieval of literatures was conducted without time restrictions using the electronic database in December 2014. Diagnostic accuracy variables were pooled and analyzed by the Meta-DiSc software. Engauge Digitizer and Stata software were used for pooled survival analysis. Twenty-two retrieved studies were eligible for systematic review, of which 9 conformed for the diagnostic test meta-analysis and 5 for the prognostic analysis. Subgroup analysis showed 24.6% pooled sensitivity and 100% pooled specificity of detections by using positive selection strategy, which moreover presented low heterogeneity. The presence of CTC was significantly associated with shorter disease free survival (DFS, HR 4.62, 95% CI 2.51-8.52). In conclusion, current evidence identifies the CTC detection assay as an extremely specific, but low sensitive test in HNSCC. Also, the presence of CTC indicates a worse DFS.
Mots clés
Biomarkers, Tumor, Carcinoma, Squamous Cell, diagnosis, Flow Cytometry, methods, Head and Neck Neoplasms, diagnosis, Humans, Neoplasm Metastasis, Neoplasm Staging, Neoplastic Cells, Circulating, pathology, Odds Ratio, Polymerase Chain Reaction, methods, Prognosis, Reproducibility of Results
Référence
Sci Rep. 2016 Feb;6:20210