Of local translation control and lipid signaling in neurons.
Fiche publication
Date publication
janvier 2019
Journal
Advances in biological regulation
Auteurs
Membres identifiés du Cancéropôle Est :
Dr VITALE Nicolas
Tous les auteurs :
Moine H, Vitale N
Lien Pubmed
Résumé
Fine-tuned regulation of new proteins synthesis is key to the fast adaptation of cells to their changing environment and their response to external cues. Protein synthesis regulation is particularly refined and important in the case of highly polarized cells like neurons where translation occurs in the subcellular dendritic compartment to produce long-lasting changes that enable the formation, strengthening and weakening of inter-neuronal connection, constituting synaptic plasticity. The changes in local synaptic proteome of neurons underlie several aspects of synaptic plasticity and new protein synthesis is necessary for long-term memory formation. Details of how neuronal translation is locally controlled only start to be unraveled. A generally accepted view is that mRNAs are transported in a repressed state and are translated locally upon externally cued triggering signaling cascades that derepress or activate translation machinery at specific sites. Some important yet poorly considered intermediates in these cascades of events are signaling lipids such as diacylglycerol and its balancing partner phosphatidic acid. A link between these signaling lipids and the most common inherited cause of intellectual disability, Fragile X syndrome, is emphasizing the important role of these secondary messages in synaptically controlled translation.
Mots clés
Diacylglycerol, Diacylglycerol kinase, FMRP, Fragile X syndrome, Local protein synthesis, Phosphatidic acid
Référence
Adv Biol Regul. 2019 Jan;71:194-205