Exocytosis: the chromaffin cell as a model system.
Fiche publication
Date publication
octobre 2002
Journal
Annals of the New York Academy of Sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BADER Marie-France, Dr VITALE Nicolas
Tous les auteurs :
Bader MF, Holz RW, Kumakura K, Vitale N
Lien Pubmed
Résumé
Neurons and neuroendocrine cells release transmitters and hormones by exocytosis of secrctory vesicles or granules. Among the cell models that have provided insight into the molecular machinery underlying the successive steps of exocytosis, adrenal chromaffin cells have taken a prominent place. Thus, most of the molecular players that orchestrate the formation, targeting, docking, and fusion of secrctory granules have been identified in chromaffin cells. By offering the opportunity to combine the use of recent biophysical techniques allowing single-vesicle resolution and specific biochemical modifications in the protein machinery involved in exocytosis, chromaffn cells remain a powerful model to address new and still open questions in the field of secretion.
Mots clés
Actins, metabolism, Animals, Chromaffin Cells, metabolism, Exocytosis, Protein Binding, Signal Transduction
Référence
Ann. N. Y. Acad. Sci.. 2002 Oct;971:178-83