X-linked mental retardation: focus on synaptic function and plasticity.
Fiche publication
Date publication
avril 2009
Journal
Journal of neurochemistry
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHELLY Jamel, Dr VITALE Nicolas
Tous les auteurs :
Humeau Y, Gambino F, Chelly J, Vitale N
Lien Pubmed
Résumé
Among mental disorders, mental retardation has been shown to be caused by various factors including a large array of genetic mutations. On the basis of remarkable progress, the emerging view is that defects in the regulation of synaptic activity and morphogenesis of dendritic spines are apparently common features associated with mutations in several genes implicated in mental retardation. In this review, we will discuss X-linked MR-related gene products that are potentially involved in the normal structure and function of the synapses, with a particular focus on pre- and/or post-synaptic plasticity mechanisms. Progress in understanding the underlying conditions leading to mental retardation will undoubtedly be gained from a closer collaboration of geneticists, physiologists and cognitive neuroscientists, which should enable the establishment of standardized approaches.
Mots clés
Animals, Dendritic Spines, genetics, Humans, Mental Retardation, X-Linked, genetics, Mutation, genetics, Neuronal Plasticity, genetics, Phenotype, Synapses, genetics
Référence
J. Neurochem.. 2009 Apr;109(1):1-14