Lipid dynamics in exocytosis.
Fiche publication
Date publication
novembre 2010
Journal
Cellular and molecular neurobiology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CHASSEROT-GOLAZ Sylvette, Dr VITALE Nicolas
Tous les auteurs :
Chasserot-Golaz S, Coorssen JR, Meunier FA, Vitale N
Lien Pubmed
Résumé
Regulated exocytosis of neurotransmitter- and hormone-containing vesicles underpins neuronal and hormonal communication and relies on a well-orchestrated series of molecular interactions. This in part involves the upstream formation of a complex of SNAREs and associated proteins leading to the eventual fusion of the vesicle membrane with the plasma membrane, a process that enables content release. Although the role of lipids in exocytosis is intuitive, it has long been overlooked at least compared to the extensive work on SNAREs. Here, we will present the latest advances in this rapidly developing field revealing that lipids actually play an active role in exocytosis by focusing on cholesterol, 3'-phosphorylated phosphoinositides and phosphatidic acid.
Mots clés
Animals, Cholesterol, metabolism, Exocytosis, Humans, Lipid Metabolism, Models, Biological, Phosphatidic Acids, metabolism, Phosphatidylinositols, metabolism
Référence
Cell. Mol. Neurobiol.. 2010 Nov;30(8):1335-42