Senescence controls prostatic neoplasia driven by Pten loss.
Fiche publication
Date publication
janvier 2019
Journal
Molecular & cellular oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr METZGER Daniel
Tous les auteurs :
Parisotto M, Grelet E, El Bizri R, Metzger D
Lien Pubmed
Résumé
We report that Pten (phosphatase and tensin homologue) ablation in prostatic epithelial cells of adult mice promotes cell proliferation to generate prostatic intraepithelial neoplasia. Moreover, our results demonstrate that proliferating Pten-deficient cells undergo replication stress and exhibit a DNA damage response, leading to cell senescence, as seen in oncogene-induced senescence.
Référence
Mol Cell Oncol. 2019 ;6(1):1511205