Histone H2B ubiquitination: signaling not scrapping.
Fiche publication
Date publication
juin 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Dr TORA Laszlo
Tous les auteurs :
Bonnet J, Devys D, Tora L
Lien Pubmed
Résumé
Monoubiquitination of histone H2B has emerged as an important chromatin modification with roles not only in transcription but also in cell differentiation, DNA repair or mRNA processing. Recently, the genome-wide distribution of histone H2B ubiquitination in different organisms has been reported. In this review we discuss the mechanisms regulating H2B ubiquitination and its downstream effectors as well as the suggested functions for this mark in light of these recent studies.:
Référence
Drug Discov Today Technol. 2014 Jun;12:e19-27