Role of RXRbeta in platelet function and arterial thrombosis.
Fiche publication
Date publication
juin 2019
Journal
Journal of thrombosis and haemostasis : JTH
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHAMBON Pierre
Tous les auteurs :
Lüsebrink E, Warm V, Pircher J, Ehrlich A, Zhang Z, Strecker J, Chambon P, Massberg S, Schulz C, Petzold T
Lien Pubmed
Résumé
Retinoid X receptors (RXR) are a family of nuclear receptors which play critical roles in the regulation of numerous fundamental biological processes including cell proliferation, differentiation and death. Earlier studies suggested that treatment with RXR agonists attenuate platelet activation in men and mice, however, the underlying molecular mechanisms have remained insufficiently understood. To further elaborate on this issue, we characterized megakaryocyte and platelet specific RXR knockout mice to study platelet function in vitro and arterial thrombosis in vivo.
Mots clés
RXR , Nuclear receptor, platelet function, retinoids, thrombosis
Référence
J. Thromb. Haemost.. 2019 Jun 7;: