The multiple flavors of GoU pairs in RNA.
Fiche publication
Date publication
avril 2019
Journal
Journal of molecular recognition : JMR
Auteurs
Membres identifiés du Cancéropôle Est :
Dr YUSUPOV Marat, Dr YUSUPOVA Gulnara
Tous les auteurs :
Westhof E, Yusupov M, Yusupova G
Lien Pubmed
Résumé
Wobble GU pairs (or GoU) occur frequently within double-stranded RNA helices interspersed within the standard G═C and A─U Watson-Crick pairs. However, other types of GoU pairs interacting on their Watson-Crick edges have been observed. The structural and functional roles of such alternative GoU pairs are surprisingly diverse and reflect the various pairings G and U can form by exploiting all the subtleties of their electronic configurations. Here, the structural characteristics of the GoU pairs are updated following the recent crystallographic structures of functional ribosomal complexes and the development in our understanding of ribosomal translation.
Mots clés
GoU pair, anticodon, codon, mRNA, miscoding, ribosome, tRNA, tautomer
Référence
J. Mol. Recognit.. 2019 Apr 29;:e2782