Role of Elastin Peptides and Elastin Receptor Complex in metabolic and cardiovascular diseases.
Fiche publication
Date publication
avril 2019
Journal
The FEBS journal
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BLAISE Sébastien, Dr DUCA Laurent, Pr MARTINY Laurent, Dr EL BTAOURI Hassan, Dr BENNASROUNE Amar
Tous les auteurs :
Wahart A, Hocine T, Albrecht C, Henry A, Sarazin T, Martiny L, Btaouri HE, Maurice P, Bennasroune A, Romier-Crouzet B, Blaise S, Duca L
Lien Pubmed
Résumé
The Cardiovascular Continuum describes a sequence of events from cardiovascular risk factors to end-stage heart disease. It includes conventional pathologies affecting cardiovascular functions such as hypertension, atherosclerosis or thrombosis and was traditionally considered from the metabolic point of view. This Cardiovascular Continuum, originally described by Dzau and Braunwald, was extended by O'Rourke to consider also the crucial role played by degradation of elastic fibers, occurring during aging, in the appearance of vascular stiffness, another deleterious risk factor of the continuum. However, the involvement of the elastin degradation products, named elastin-derived peptides, to the Cardiovascular Continuum progression has not been considered before. Data from our lab and others clearly showed that these bioactive peptides are central regulators of this continuum, thereby amplifying appearance and evolution of cardiovascular risk factors such as diabetes or hypertension, of vascular alterations such as atherothrombosis and calcification, but also non-alcoholic fatty liver disease and non-alcoholic steatohepatitis. The Elastin Receptor Complex has been shown to be a crucial actor in these processes. We propose here the participation of these elastin-derived peptides and of the Elastin Receptor Complex in these events, and introduce a revisited Cardiovascular Continuum based on their involvement, for which elastin-based pharmacological strategies could have a strong impact in the future. This article is protected by copyright. All rights reserved.
Mots clés
Cardiovascular Continuum, ECM-based pharmacology, Elastin, Elastin Receptor Complex, Elastin-Derived Peptides, Metabolic Syndrome
Référence
FEBS J.. 2019 Apr 4;: