FTY720 controls disease severity and attenuates sciatic nerve damage in chronic experimental autoimmune neuritis.
Fiche publication
Date publication
mars 2019
Journal
Journal of neuroinflammation
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DE SEZE Jérôme
Tous les auteurs :
Kremer L, Taleb O, Boehm N, Mensah-Nyagan AG, Trifilieff E, de Seze J, Brun S
Lien Pubmed
Résumé
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an autoimmune-mediated inflammatory disease of the peripheral nervous system characterized by a response directed against certain myelin proteins and for which therapies are limited. Previous studies have suggested a beneficial role of FTY720, a sphingosine 1-phosphate (S1P) receptor agonist, known to deplete lymphocytes from the peripheral blood by sequestering them into lymph nodes, in the treatment of experimental autoimmune neuritis (EAN). Therefore, we investigated whether FTY720 is also beneficial in chronic experimental autoimmune neuritis (c-EAN), a recently developed rat model mimicking human CIDP.
Mots clés
Chronic inflammatory demyelinating polyradiculoneuropathy, FTY720, Inflammatory neuropathies, c-EAN
Référence
J Neuroinflammation. 2019 Mar 2;16(1):54