Agreement between clinicoradiological signs at diagnosis and radiohistological analysis after neoadjuvant chemotherapy of suspected Wilms tumor rupture: Consequences on therapeutic choices.
Fiche publication
Date publication
février 2019
Journal
Pediatric blood & cancer
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BERNIER-CHASTAGNER Valérie, Pr CHASTAGNER Pascal
Tous les auteurs :
Le Rouzic MA, Mansuy L, Galloy MA, Champigneulle J, Bernier V, Chastagner P
Lien Pubmed
Résumé
According to SIOP criteria, every patient presenting with preoperative Wilms tumor (WT) rupture must receive abdominal radiotherapy. Neoadjuvant chemotherapy reduces tumor volume and is responsible for the development of peritumoral capsule formation, which can mask tumor rupture on histological analysis, while it was clinically or radiologically obvious at diagnosis. Yet, there are no protocol recommendations for this particular presentation.
Mots clés
Wilms tumor, children, histology, radiology, rupture, therapeutic choices
Référence
Pediatr Blood Cancer. 2019 Feb 17;:e27674