[Protein molecular aging: which role in physiopathology?]
Fiche publication
Date publication
février 2017
Journal
Medecine sciences : M/S
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe
Tous les auteurs :
Jaisson S, Desmons A, Gorisse L, Gillery P
Lien Pubmed
Résumé
Protein molecular aging corresponds to all modifications affecting proteins during their biological life, which lead to the alteration of their structural and functional properties. This phenomenon participates in cell and tissue aging and is therefore involved in the aging of human organism. It is also amplified in various chronic diseases such as diabetes mellitus or chronic kidney disease, where it participates in the development of long-term complications. This review aims at describing the main reactions responsible for molecular aging, their impact on protein properties and the parameters which could influence this phenomenon. A general scheme explaining its role in physiopathology is also proposed.
Mots clés
Animals, Cellular Senescence, physiology, Disease, etiology, Glycosylation, Humans, Oxidation-Reduction, Protein Carbonylation, Protein Denaturation, Protein Processing, Post-Translational, Proteins, chemistry
Référence
Med Sci (Paris). 2017 Feb;33(2):176-182