Nacre, a natural, multi-use, and timely biomaterial for bone graft substitution.
Fiche publication
Date publication
février 2017
Journal
Journal of biomedical materials research. Part A
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLET Pierre, Pr MAINARD Didier
Tous les auteurs :
Zhang G, Brion A, Willemin AS, Piet MH, Moby V, Bianchi A, Mainard D, Galois L, Gillet P, Rousseau M
Lien Pubmed
Résumé
During the past two decades, with a huge and rapidly increasing clinical need for bone regeneration and repair, bone substitutes are more and more seen as a potential solution. Major innovation efforts are being made to develop such substitutes, some having advanced even to clinical practice. It is now time to turn to natural biomaterials. Nacre, or mother-of-pearl, is an organic matrix-calcium carbonate coupled shell structure produced by molluscs. In vivo and in vitro studies have revealed that nacre is osteoinductive, osteoconductive, biocompatible, and biodegradable. With many other outstanding qualities, nacre represents a natural and multi-use biomaterial as a bone graft substitute. This review aims at summarising the current needs in orthopaedic clinics and the challenges for the development of bone substitutes; most of all, we systematically review the physiological characteristics and biological evidence of nacre's effects centred on osteogenesis, and finally we put forward the potential use of nacre as a bone graft substitute. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 662-671, 2017.
Mots clés
biomaterial, biomineralization, bone graft substitute, clinical applications, nacre
Référence
J Biomed Mater Res A. 2017 Feb;105(2):662-671