ECDomainMiner: discovering hidden associations between enzyme commission numbers and Pfam domains.
Fiche publication
Date publication
février 2017
Journal
BMC bioinformatics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DEVIGNES Marie-Dominique
Tous les auteurs :
Alborzi SZ, Devignes MD, Ritchie DW
Lien Pubmed
Résumé
Many entries in the protein data bank (PDB) are annotated to show their component protein domains according to the Pfam classification, as well as their biological function through the enzyme commission (EC) numbering scheme. However, despite the fact that the biological activity of many proteins often arises from specific domain-domain and domain-ligand interactions, current on-line resources rarely provide a direct mapping from structure to function at the domain level. Since the PDB now contains many tens of thousands of protein chains, and since protein sequence databases can dwarf such numbers by orders of magnitude, there is a pressing need to develop automatic structure-function annotation tools which can operate at the domain level.
Mots clés
Content-based filtering, Enzyme commission number, Pfam domain, Protein domain, Protein function
Référence
BMC Bioinformatics. 2017 Feb;18(1):107