Differential morphological and functional features of fibroblasts explanted from Solar Lentigo.
Fiche publication
Date publication
février 2017
Journal
The British journal of dermatology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HUMBERT Philippe
Tous les auteurs :
Goorochurn R, Viennet C, Tissot M, Locatelli F, Granger C, Varin-Blank N, Humbert P, Le Roy C
Lien Pubmed
Résumé
Upon ageing, chronic exposure to ultraviolet radiations and pollution induces benign hyper-pigmented lesions, such as Solar Lentigo maculae (SL) (1) . Well-defined histologically, SL is distinguishable from other hyper-pigmented diseases and can be classified relative to its evolution (2-4) . Differential gene-profiling analyses comparing SL and normal skin biopsies revealed that SL tissues are mainly composed of epidermal activated melanocytes as well as hypo-proliferating and hypo-differentiated keratinocytes with a background of chronic inflammation. In absence of fibroblast markers, immuno-staining analyses for several growth factors and secreted proteins in the upper dermis of SL biopsies strongly suggest that dermal fibroblasts contribute functionally to dysregulation of epidermal cells (5) . These observations are strengthened by recent studies using a pigmented reconstructed skin model that demonstrates the influence of dermal fibroblasts on skin pigmentation (6) . However, data on the morphological and functional features of the SL primary fibroblasts that could explain their role in SL disease are not available. This article is protected by copyright. All rights reserved.
Mots clés
Adult, Cell Movement, physiology, Cell Proliferation, physiology, Fibroblasts, pathology, Humans, Lentigo, pathology, Models, Biological, Sunlight, adverse effects
Référence
Br. J. Dermatol.. 2017 Feb;: