Antithymocyte globulins in renal transplantation-from lymphocyte depletion to lymphocyte activation: The doubled-edged sword.
Fiche publication
Date publication
février 2017
Journal
Transplantation reviews (Orlando, Fla.)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DUCLOUX Didier
Tous les auteurs :
Bamoulid J, Crépin T, Courivaud C, Rebibou JM, Saas P, Ducloux D
Lien Pubmed
Résumé
Compelling data suggest that lymphocyte depletion following T cell depleting therapy may induce prolonged CD4 T cell lymphopenia and trigger lymphocyte activation in some patients. These profound and non-reversible immune changes in T cell pool subsets are the consequence of both impaired thymic renewal and peripheral homeostatic proliferation. Chronic viral challenges by CMV play a major role in these immune alterations. Even when the consequences of CD4 T cell lymphopenia have been now well described, recent studies shed new light on the clinical consequences of immune activation. In this review, we will first focus on the mechanisms involved in T cell pool reconstitution after T cell depletion and further consider the clinical consequences of ATG-induced T cell activation and senescence in renal transplant recipients.
Mots clés
Antilymphocyte Serum, physiology, Humans, Kidney Transplantation, Lymphocyte Activation, physiology, Lymphocyte Depletion, T-Lymphocytes, physiology, Transplantation Immunology, physiology
Référence
Transplant Rev (Orlando). 2017 Feb;: