Cytokines during periodontal wound healing: potential application for new therapeutic approach.
Fiche publication
Date publication
avril 2017
Journal
Oral diseases
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BENKIRANE-JESSEL Nadia
Tous les auteurs :
Morand DN, Davideau JL, Clauss F, Jessel N, Tenenbaum H, Huck O
Lien Pubmed
Résumé
Regeneration of periodontal tissues is one of the main goals of periodontal therapy. However, current treatment, including surgical approach, use of membrane to allow maturation of all periodontal tissues, or use of enamel matrix derivatives, presents limitations in their indications and outcomes leading to the development of new tissue engineering strategies. Several cytokines are considered as key molecules during periodontal destruction process. However, their role during each phase of periodontal wound healing remains unclear. Control and modulation of the inflammatory response and especially, release of cytokines or activation/inhibition in a time- and spatial-controlled manner may be a potential perspective for periodontal tissue engineering. The aim of this review was to summarize the specific role of several cytokines during periodontal wound healing and the potential therapeutic interest of inflammatory modulation for periodontal regeneration especially related to the expression sequence of cytokines.
Mots clés
cytokines, periodontitis, regenerative medicine, scaffold, wound healing
Référence
Oral Dis. 2017 Apr;23(3):300-311