Towards the formulation of stable micro and nano double emulsions through silica coating of internal water droplets.
Fiche publication
Date publication
janvier 2019
Journal
Langmuir : the ACS journal of surfaces and colloids
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MELY Yves, Mme MESSADDEQ Nadia
Tous les auteurs :
Akram S, Wang X, Vandamme TF, Collot M, Rehman AU, Messaddeq N, Mély Y, Anton N
Lien Pubmed
Résumé
Delivery systems able to co-encapsulate both hydrophilic and hydrophobic species are of great interest for both fundamental research and industrial applications. Water-in-oil-in-water (w/O/W) emulsions are interesting systems for this purpose, but they suffer from limited stability. In this study we propose an innovative approach to stabilize double emulsions by the synthesis of a silica membrane at the water / oil interface of the primary emulsion ( i.e. inner w/O emulsion). This approach allows the formulation of stable double emulsions through a two-step process, enabling high encapsulation efficiencies of model hydrophilic dyes encapsulated in the internal droplets. This approach also decreases the scale of the double droplets up to the nano-scale, which is not possible without silica stabilization. Different formulation and process parameters were explored in order to optimize the methodology. Physicochemical characterization was performed by dynamic light scattering, encapsulation efficiency measurements, release profiles, as well as by optical and transmission electron microscopies.
Référence
Langmuir. 2019 Jan 10;: