Impairment of glyoxalase-1, an advanced glycation end-product detoxifying enzyme, induced by inflammation in age-related osteoarthritis.
Fiche publication
Date publication
janvier 2019
Journal
Arthritis research & therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GILLERY Philippe
Tous les auteurs :
Trellu S, Courties A, Jaisson S, Gorisse L, Gillery P, Kerdine-Römer S, Vaamonde-Garcia C, Houard X, Ekhirch FP, Sautet A, Friguet B, Jacques C, Berenbaum F, Sellam J
Lien Pubmed
Résumé
Accumulation of advanced glycation end-products (AGEs) is involved in age-related osteoarthritis (OA). Glyoxalase (Glo)-1 is the main enzyme involved in the removal of AGE precursors, especially carboxymethyl-lysine (CML). We aimed to investigate the expression of several AGEs and Glo-1 in human OA cartilage and to study chondrocytic Glo-1 regulation by inflammation, mediated by interleukin (IL)-1β.
Mots clés
Advanced glycation end-product, Aging, Carboxymethyl-lysine, Chondrocyte, Glyoxalase, Osteoarthritis
Référence
Arthritis Res. Ther.. 2019 Jan 11;21(1):18